Effects of neoadjuvant chemotherapy on minimum alveolar concentration values of sevofurane and desfurane in patients with hepatocellular carcinoma complicated with jaundice

The effects of neoadjuvant chemotherapy on the minimum alveolar concentration (MAC) values of sevofurane and desfurane in patients with hepatocellular carcinoma (HCC) complicated with jaundice were investigated. Eighty patients with HCC complicated with jaundice were selected. Forty patients underwent the neoadjuvant chemotherapy and were grouped into the desfurane group (Group D) and the sevofurane group (Group S). Patients in all chemotherapy groups received 2 cycles of chemotherapy prior to surgery and underwent surgical treatment 3 weeks after chemotherapy. The remaining 40 patients in the control group were divided into the desfurane group (Group C1) and the sevofurane group (Group C2). Changes in MAP, HR and BIS at different time points before and after anesthesia induction and skin incision were compared among the groups. Results showed that there were no significant differences in MAP, HR and BIS before anesthesia induction (T0) (P>0.05); at each time point from T1 to T6, MAP, HR and BIS of Group D were significantly lower than those of Group C1 (P>0.05). Furthermore, MAP, HR and BIS of Group S were significantly lower than those of Group C2 (P>0.05). The [MAC.sub.Mean] of sevofurane and desfurane were compared among all patient groups using the mean method. [MAC.sub.Mean] values of Group D were significantly lower than those of Group C1 (P