Significance of mucin expression in pancreatic intraepithelial neoplasia

Significance of mucin expression in pancreatic intraepithelial neoplasia

Purpose: To evaluate chosen mucins (mucin 1, 4, 5AC) expression in pancreatic intraepithelial neoplasia, which is a precursor lesion of pancreatic ductal adenocarcinoma. Materials and methods: The study group included 70 patients operated on due to inflammation, cysts and pancreatic ductal adenocarc...

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Veröffentlicht in:Progress in health sciences 2018-06, Vol.8 (1), p.63
Hauptverfasser: Zinczuk, J, Zareba, K, Pryczynicz, A, Kuczynska, P, Boron, Z, Ustymowicz, W, Maciorkowska, M, Cwiklinska-Dworakowska, M, Baszun, M, Jelski, S, Guzinska-Ustymowicz, K
Format: Artikel
Sprache:eng
Schlagworte:
Gene expression
Genetic aspects
Immunohistochemistry
Pancreatic cancer
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Zusammenfassung:Purpose: To evaluate chosen mucins (mucin 1, 4, 5AC) expression in pancreatic intraepithelial neoplasia, which is a precursor lesion of pancreatic ductal adenocarcinoma. Materials and methods: The study group included 70 patients operated on due to inflammation, cysts and pancreatic ductal adenocarcinoma with pancreatic intraepithelial neoplasia revealed additionally. Mucin 1, 4 and 5AC expression was assessed by immunohistochemical method using polyclonal antibodies. Results: Statistical analysis proved a positive correlation between the expression of mucin 1, 4 and 5AC proteins and the presence and staging of pancreatic intraepithelial neoplasia (p
ISSN:2083-1617