Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin

Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin

Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H 2 O. The solubility and dissolution rate of indomethacin from SDs i...

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Veröffentlicht in:Pharmaceutical chemistry journal 2018-06, Vol.52 (3), p.241-244
Hauptverfasser: Krasnyuk, I. I., Kosheleva, T. M., Belyatskaya, A. V., Stepanova, O. I., Skovpen, Yu, Grikh, V. V., Ovsyannikova, L. V.
Format: Artikel
Sprache:eng
Schlagworte:
Indomethacin
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Polyethylene glycol
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Zusammenfassung:Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H 2 O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-018-1799-0