Effect of dihydroarteminin combined with siRNA targeting Notchl on Notchl/c-Myc signaling in T-cell lymphoma cells

The effectiveness of therapy combining dihydroartemisinin (DHA) and small interfering RNA targeting Notch1 (siNotch1) in T-cell lymphoma remains unknown. The present study explored the potential and possible mechanisms of combined dihydroarteminin, and siNotch1 therapy for T-cell lymphoma. It was de...

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Veröffentlicht in:	Experimental and therapeutic medicine 2018-03, Vol.15 (3), p.3059
Hauptverfasser:	Huo, Lanfen, Wei, Wenwen, Wu, Shaoling, Zhao, Xindong, Zhao, Chunting, Zhao, Hongguo, Sun, Lingjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Cellular signal transduction Development and progression Genetic aspects Health aspects Innovations Lymphomas Molecular targeted therapy Oncogenes Plant products
Online-Zugang:	Volltext
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Zusammenfassung:	The effectiveness of therapy combining dihydroartemisinin (DHA) and small interfering RNA targeting Notch1 (siNotch1) in T-cell lymphoma remains unknown. The present study explored the potential and possible mechanisms of combined dihydroarteminin, and siNotch1 therapy for T-cell lymphoma. It was demonstrated that the viability rates of siRNA-DHA-treated cells was significantly suppressed in comparison with those in control cells, control siRNA cells, siRNA-treated cells and DHA-treated cells (P
ISSN:	1792-0981
DOI:	10.3892/etm.2018.5784