Synthesis and Biological Activity of [beta]-Aroylacrylate Salts

Synthesis and Biological Activity of [beta]-Aroylacrylate Salts

A series of [beta]-p-toluylacrylate salts with various amines that retained the molecular fragment responsible for the antibacterial activity were synthesized. A new efficient method for obtaining [beta]-aroylvinyl-1-pyridinium and -triphenylphosphonium bromides was proposed. Antibacterial testing s...

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Veröffentlicht in:Pharmaceutical chemistry journal 2018-01, Vol.51 (10), p.873
Hauptverfasser: Khachikyan, R. Dzh, Ovakimyan, Z. G, Mikaelyan, A. A, Paronikyan, R. V, Stepanyan, G. M
Format: Artikel
Sprache:eng
Schlagworte:
Antibacterial agents
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Zusammenfassung:A series of [beta]-p-toluylacrylate salts with various amines that retained the molecular fragment responsible for the antibacterial activity were synthesized. A new efficient method for obtaining [beta]-aroylvinyl-1-pyridinium and -triphenylphosphonium bromides was proposed. Antibacterial testing showed that all investigated compounds possessed antibacterial properties.
ISSN:0091-150X
DOI:10.1007/s11094-018-1707-7