Search for Bactericides Among Derivatives of Deoxyvasicinone, Mackinazolinone, and Thienopyrimidinones

Series of arylidene- and arylhydroxymethyl derivatives of 1,2,3,9-tetrahydropyrrolo[2,1- b ]quinazolin-3-one and 2,3,4,10-tetrahydro-1 H -pyrido[2,1- b ]quinazolin-10-one were synthesized. Schiff bases were synthesized from amine derivatives. Hydroxymethylidene derivatives and arylaminomethylidene-1,2,3,9-tetrahydropyrrolo[2,1- b ]quinazolin-9-ones and -2,3,4,10-tetrahydro-1 H -pyrido[2,1- b ]quinazolin-10-ones were obtained. The antimicrobial activity of the synthesized compounds against S. aureus , E. coli , Bacillus cereus , Candida albicans , and Pseudomonas aeruginosa was studied. It was concluded that the search for bactericides in these series was promising.