Synthesis of O- tyrosine schiff's base precursor

O-(1'-[.sup.18F]fluoropropan-2'-yl)-l-tyrosine (1-[.sup.18F]FPT) was synthesized using the Ni(II)-(S)-[N-2-(N'-benzylprolyl)amino]benzophenone-S-tyrosine based precursor. The precursor was synthesized through a two-step process starting from RS-tyrosine, (S)BPB and Ni(II) chloride hexahydrate. The precursor was [.sup.18F]radiofluorinated, followed by hydrolysis with 2 M HCl to obtain 1-[.sup.18F]FPT. The reaction mixture was purified using neutral alumina column. Radiolabeling efficiency and radiochemical yield (after purification and decay uncorrected) was 60 and 5% respectively. Total time for synthesis was 70 min. This synthesis procedure for (1-[.sup.18F]FPT) gave a radiochemical purity of 98% with enantiomeric purity of 93%, and can easily be adapted in any standard 2-[.sup.18F]FDG synthesis module.