In vitro synergistic activity of lidocaine and miconazole against Candida albicans/Atividade sinergica in vitro de lidocaina e miconazole contra Candida albicans

Candida albicans is the main yeast isolated from vulvovaginal candidiasis(VVC) and a major antifungal used to treat VVC is miconazole (MZ), it shows local toxic effects, such as irritation and burns. The lidocaine (LD) is a local anesthetic. The aim of this study was to evaluate the synergistic activity of LD/MZ against 19 strains of C. albicans isolated from vaginal secretion. 78.9% of the strains were susceptible to the combination LD/MZ, demonstrating synergism of drugs. These drugs can be used to produce vaginal creams to treat VVC, especially drug resistant. Keywords: vulvovaginal candidiasis, antifungal agents, local anesthetic. RESUMO. Candida albicans e a principal levedura isolada de candidiase vulvovaginal (CVV) e o principal antifungico usado para tratar a VVC e miconazol (MZ), que apresenta efeitos toxicos locais, tais como irritacao e queimaduras. A lidocaina (LD) e um anestesico local. O objetivo deste estudo foi avaliar a atividade sinergica de LD/MZ contra 19 cepas de C. albicans isoladas de secrecao vaginal. Foram suscetiveis a combinacao LD/MZ, 78.9% das cepas testadas, demonstrando sinergismo de drogas. Estes farmacos podem ser utilizados para a producao de cremes vaginais para tratar VVC, especialmente aquelas resistentes aos farmacos dispomveis. Palavras-chave: candidiase vulvovaginal, agentes antifungicos, anestesico local.