Studying the general toxicity and cumulative properties of a radiopharmaceutical nanocolloid, [sup.99m]Tc-[Al.sub.2][O.sub.3]

We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, [sup.99m]Tc-[Al.sub.2][O.sub.3]. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect. Key Words: radiopharmaceutical; acute toxicity; cumulation; subchronic toxicity; preclinical trials