Isolated microorganisms and their antibiotic sensitivity patterns of Namazi Hospital neonatal intensive care unit

Infections are important causes of morbidity, mortality and prolonged admission among the neonates. It is necessary to treat neonatal infections by empirical antimicrobial drugs, based on the epidemiologic studies of bacterial sensitivity. This study aims to determine the microorganisms involved in neonatal infections and their antibiotic sensitivity patterns. This cross-sectional study enrolled 200 neonates admitted to the central neonatal intensive care unit (NICU) of Shiraz Namazi Hospital from Oct 2013 to March 2014. Samples included blood, urine, CSF, stool, eye discharge, peritoneal fluid, ear secretion and nasal discharge. All the samples underwent culture and antibiotic sensitivity pattern. Statistical analyses were performed using version 16 SPSS software. Totally, 35% of the specimens were positive for microbial agents. The most isolated microorganisms from all samples were Staphylococcusepidermidis(Staph. epidermis) (26.8%) and klebsiella (17.7%). In the nasal and throat samples, Klebsiella was the most isolated microorganism. All Staph.epidermis isolates were sensitive to vancomycin.Staph.epidermis was most resistant to tocloxacilin and erythromycin. Pathogens responsible for neonatal infections and their antibiotic sensitivity patterns may vary over time and with hospitals. So monitoring the microbial epidemiology of neonatal infections and their susceptibility patterns is necessary to choose appropriate antibiotics. Key words: Neonatal Intensive Care Unit; Infection; microorganisms; Antimicrobial Resistance.