[nu] and [beta]1 Integrins Mediate A[beta]-Induced Neurotoxicity in Hippocampal Neurons via the FAK Signaling Pathway

[alpha][nu] and [beta]1 integrins mediate A[beta]-induced neurotoxicity in primary hippocampal neurons. We treated hippocampal neurons with 2.5 [micro]g/mL 17E6 and 5 [micro]g/mL ab58524, which are specific [alpha][nu] and [beta]1 integrin antagonists, respectively, for 42 h prior to 10 [micro]M A[b...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e64839
Hauptverfasser:	Han, Hai-Yan, Zhang, Jin-Ping, Ji, Su-Qiong, Liang, Qi-Ming, Kang, Hui-Cong, Tang, Rong-Hua, Zhu, Sui-Qiang, Xue, Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic aspects Integrins Physiological aspects Protein kinases
Online-Zugang:	Volltext
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