A Toolbox for Tuberculosis . Evaluation of QuantiFERON-TB Gold in Tube for TB Diagnosis

A Toolbox for Tuberculosis . Evaluation of QuantiFERON-TB Gold in Tube for TB Diagnosis

Background The aim of this multicentric prospective study in India was to assess the performance of the QuantiFERON TB-Gold in tube (QFT-GIT), Tuberculin Skin Test (TST) and microbiological results as additional tools for diagnosing active tuberculosis (TB) and latent infection (LTBI) according to H...

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Veröffentlicht in:PloS one 2013-09, Vol.8 (9), p.e73579
Hauptverfasser: Lagrange, Philippe H, Thangaraj, Satheesh K, Dayal, Rajeshwar, Deshpande, Alaka, Ganguly, Nirmal K, Girardi, Enrico, Joshi, Beenu, Katoch, Kiran, Katoch, Vishwa M, Kumar, Manoj, Lakshmi, Vemu, Lepo, Longuet, Christophe, Malladi, Subbalaxmi V. S, Mukerjee, Deepali, Nair, Deepthi, Raja, Alamelu, Raman, Balambal, Rodrigues, Camilla, Sharma, Pratibha, Singh, Amit, Singh, Sarman, Sodha, Archana, Kabeer, Basirudeen Syed Ahamed, Vernet, Guy, Goletti, Delia
Format: Artikel
Sprache:eng
Schlagworte:
Diagnosis
Health aspects
HIV
HIV infections
Tuberculosis
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Zusammenfassung:Background The aim of this multicentric prospective study in India was to assess the performance of the QuantiFERON TB-Gold in tube (QFT-GIT), Tuberculin Skin Test (TST) and microbiological results as additional tools for diagnosing active tuberculosis (TB) and latent infection (LTBI) according to Human Immunodeficiency Virus (HIV) status. Methods Individuals with and without active TB and HIV infection were enrolled between 2006-2008. QFT-GIT and TST results were analyzed per se and in combination with microbiological data. Results Among the 276 individuals (96 active pulmonary TB and 180 no active TB) tested by QFT-GIT, 18 indeterminate results (6.5%) were found, more significantly numerous in the HIV-infected (15/92; 16.3%) than the HIV-uninfected (3/184; 1.6%)(p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0073579