Cerebrospinal Fluid Melanin-Concentrating Hormone in Alzheimer's Disease

Cerebrospinal Fluid Melanin-Concentrating Hormone in Alzheimer's Disease

Ancillary to decline in cognitive abilities, patients with Alzheimer's disease (AD) frequently suffer from behavioural and psychological symptoms of dementia (BPSD). Hypothalamic polypeptides such as melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) are promoters of sleep-...

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Veröffentlicht in:PloS one 2013-05, Vol.8 (5), p.e63136
Hauptverfasser: Schmidt, Frank M, Kratzsch, Juergen, Gertz, Hermann-Josef, Tittmann, Mandy, Jahn, Ina, Pietsch, Uta-Carolin, Kaisers, Udo X, Thiery, Joachim, Hegerl, Ulrich, Schönknecht, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Advertising executives
Alzheimer's disease
Biopolymers
Brain
Energy law
Hormones
Sleep
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Zusammenfassung:Ancillary to decline in cognitive abilities, patients with Alzheimer's disease (AD) frequently suffer from behavioural and psychological symptoms of dementia (BPSD). Hypothalamic polypeptides such as melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) are promoters of sleep-wake regulation and energy homeostasis and are found to impact on cognitive performance. To investigate the role of MCH and HCRT-1 in AD, cerebrospinal fluid (CSF) levels were measured in 33 patients with AD and 33 healthy subjects (HS) using a fluorescence immunoassay (FIA). A significant main effect of diagnosis (F(1,62) = 8.490, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0063136