New Synthesis and Analgesic and Diuretic Activity of Halo-Substituted 4-Hydroxy-1-Methyl-2,2-Dioxo- 1H-2[lambda].sup.6,1-Benzothiazine-3-Carboxanilides

New Synthesis and Analgesic and Diuretic Activity of Halo-Substituted 4-Hydroxy-1-Methyl-2,2-Dioxo- 1H-2[lambda].sup.6,1-Benzothiazine-3-Carboxanilides

A simple new method for synthesizing N-aryl-4-hydroxy-1-methyl-2,2-dioxo-1H-2[lambda].sup.6,1-benzothiazine-3-carboxamides in high yields is proposed. A series of halo-substituted derivatives were synthesized. Their PMR and .sup.13C NMR spectra and mass spectrometric characteristics were studied. Pr...

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Veröffentlicht in:Pharmaceutical chemistry journal 2016-12, Vol.50 (9), p.589
Hauptverfasser: Ukrainets, I. V, Petrushova, L. A, Dzyubenko, S. P, Grinevich, L. A
Format: Artikel
Sprache:eng
Schlagworte:
Diuretics
Mass spectrometry
Opioids
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Zusammenfassung:A simple new method for synthesizing N-aryl-4-hydroxy-1-methyl-2,2-dioxo-1H-2[lambda].sup.6,1-benzothiazine-3-carboxamides in high yields is proposed. A series of halo-substituted derivatives were synthesized. Their PMR and .sup.13C NMR spectra and mass spectrometric characteristics were studied. Preliminary pharmacological screening showed that the investigated class of compounds was promising for designing potential analgesics and diuretics, thereby confirming the highly effective "flip-flop drug" methodology.
ISSN:0091-150X
DOI:10.1007/s11094-016-1496-9