Synthesis and Antiproliferative Activity of New Acylcatechins

Synthesis and Antiproliferative Activity of New Acylcatechins

New peracyl derivatives of the natural flavonoid (±)-catechin were synthesized. It was shown that carboxylic-acid acyl residues enhanced to various degrees the cytotoxicity of peracyl catechins against HeLa cell line. The structures of the synthesized compounds were confirmed by PMR and 13 C NMR spe...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutical chemistry journal 2016-11, Vol.50 (8), p.523-525
Hauptverfasser: Pozdeev, A. O., Rasadkina, E. N., Burym, A. A., Knyazev, V. V., Koroteev, M. P., Matyushin, A. I., Koroteev, A. M., Semeikin, A. V., Shimanovskii, N. L.
Format: Artikel
Sprache:eng
Schlagworte:
Flavonoids
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:New peracyl derivatives of the natural flavonoid (±)-catechin were synthesized. It was shown that carboxylic-acid acyl residues enhanced to various degrees the cytotoxicity of peracyl catechins against HeLa cell line. The structures of the synthesized compounds were confirmed by PMR and 13 C NMR spectroscopy and elemental analysis. The catechins were compared with previously studied analogous dihydroquercetin derivatives.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1481-3