Four-Step Synthesis of Abiraterone Acetate from Dehydroepiandrosterone

Four-Step Synthesis of Abiraterone Acetate from Dehydroepiandrosterone

A four-step synthesis of abiraterone acetate in good yield was developed. The synthesis employed Suzuki cross-coupling in the key step and produced the target compound in 99.8% purity.

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Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutical chemistry journal 2016-09, Vol.50 (6), p.404-406
Hauptverfasser: Balaev, A. N., Gromyko, A. V., Fedorov, V. E.
Format: Artikel
Sprache:eng
Schlagworte:
Acetates
Cancer metastasis
Cytochrome P-450
Dehydroepiandrosterone
Drug Synthesis Methods and Manufacturing Technology
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Physiological aspects
Prostate cancer
Sex hormones
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Beschreibung
Zusammenfassung:A four-step synthesis of abiraterone acetate in good yield was developed. The synthesis employed Suzuki cross-coupling in the key step and produced the target compound in 99.8% purity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1459-1