Synthesis, Structure, and Analgesic Properties of Phosphorylated Dihydro-1,4-Benzodiazepin-2-Ones

Synthesis, Structure, and Analgesic Properties of Phosphorylated Dihydro-1,4-Benzodiazepin-2-Ones

Condensation of 3-hydroxy-5-aryl-1.2-dihydro-3 H -1.4-benzodiazepin-2-ones with diphenylchlorophosphine was found to produce 3- or 5-diphenylphosphine oxides with high analgesic activity; ED 50 values were (0.08 ± 0.02) – (0.97 ± 0.27) mg/kg.

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Veröffentlicht in:Pharmaceutical chemistry journal 2016-08, Vol.50 (4), p.229-233
Hauptverfasser: Pavlovskii, V. I., Gololobov, Yu. G., Andronati, S. A., Voronenko, E. V., Kabanova, T. A., Khalimova, E. I., Krasnova, I. Yu, Khrustalev, V. N.
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Tranquilizing agents
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Zusammenfassung:Condensation of 3-hydroxy-5-aryl-1.2-dihydro-3 H -1.4-benzodiazepin-2-ones with diphenylchlorophosphine was found to produce 3- or 5-diphenylphosphine oxides with high analgesic activity; ED 50 values were (0.08 ± 0.02) – (0.97 ± 0.27) mg/kg.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1428-8