Effects of a new intravenous electrolyte solution for veterinary therapy on the electrolyte and acid-base balances of healthy horses/Efeito de ma nova solucao eletrolitica intravenosa para uso veterinario sobre os equilibrios eletrolitico e acido base de equinos sadios

The effects of a new intravenous electrolyte solution for veterinary therapy on electrolyte and acid-base balances of horses were evaluated, assessing the potential of the use of this solution as a rational alternative in fluid therapy. Eight healthy adult horses, including 4 males and 4 females, received two treatments in a cross-over design: isotonic saline solution (IS) and a test solution (TS) containing 145mEq of [Na.sup.+], 5mEq of [K.sup.+], 4mEq of [Ca.sup.++], 2mEq of [Mg.sup.++], 96mEq of [Cl.sup.-], 60mEq of lactate, 50g of dextrose, and 4mg of cyanocobalamin per liter. Solutions were IV infused in a volume corresponding to 5% of BW, over 3 hours. Venous blood samples were taken 5 times before and after the infusion (at 0, 3, 6, 9 e 24h), for pHv, pC[O.sub.2]v, HC[O.sub.3]-v, BEv, [Na.sup.+], [K.sup.+], [Cl.sup.-], [Ca.sup.++], Ca, P, Mg, glucose and L-lactate measurements, and AG and SID calculations. The data were analyzed through repeated measures ANOVA. The IS caused mild acidifying effect by increasing [Cl.sup.-] and decreasing plasma SID. In contrast, the TS induced mild and transient hypochloremia without changes in acid-base balance. Hyperglycemia was present at the end of the TS infusion and reversed 6 hours later. The horses did not exhibit any clinical changes. We concluded that TS is an option for fluid therapy in horses. Key words: fluid therapy, electrolyte, strong ion difference, rehydration. Considerando a possibilidade de ser empregada como alternativa racional na terapia com fluidos, avaliaram-se os efeitos de uma nova solucao eletrolitica intravenosa, desenvolvida para uso veterinario, sobre os equilibrios eletrolitico e acido base de equinos. Oito equinos adultos sadios, quatro machos e quatro femeas, foram submetidos a dois tratamentos em delineamento cross-over: solucao salina isotonica (SI) e solucao teste (ST), composta por 145mEq de [Na.sup.+], 5mEq de K+, 4mEq de Ca++, 2mEq de [Mg.sup.++], 96mEq de Cl-, 60mEq de lactato, 50g de dextrose e 4mg de cianocobalamina por litro. As solucoes foram administradas por via intravenosa, em volume correspondente a 5% do peso corporal, durante tres horas de infusao continua. Amostras de sangue venoso foram colhidas em cinco momentos, antes e apos a infusao (0, 3, 6, 9 e 24h), para determinacoes de pHv, pC[O.sub.2]v, HCO3-v, BEv, [Na.sup.+], K+, Cl-, Ca++, Ca, P, Mg, glicose e lactato L, e para calculo de AG e SID. Os resultados foram analisados por analise de variancia de medidas repe