Lissencephaly-pachygyria and cerebellar hypoplasia in a calf/ Lisencefalia-paquigiria e hipoplasia cerebelar em um bovino

A case of lissencephaly-pachygyria and cerebellar hypoplasia diagnosed in a Charolais x Tabapua calf is described. The calf presented since birth, clinical signs characterized by apathy, prolonged recumbency, tremors of the head and neck, ataxia, hypermetria, difficulty walking, blindness and swelling of the joints of the four limbs. Due to the unfavorable prognosis, the animal was euthanized and necropsied at 34 days of age. At necropsy, a rudimentary development of the brain folds (gyri) and grooves (sulci) was observed, and the cerebellum was hypoplastic. The cut surface of the brain exhibited thickening of the gray matter (pachygyria) in the frontal, parietal, temporal and occipital cortices and narrowing of the white matter. In the organs of the thoracic and abdominal cavities, no significant lesions were observed. Histologically, cerebral cortex was thick and exhibited neuronal disorganization of the gray matter. The cerebellum had a thin molecular layer, and neuronal disorganization with ectopia of the Purkinje neurons in the region of the granular and molecular layers. There were no bacterial growths in cultures of joint swabs. This was the only case on the property, which suggests that this malformation, which has not previously been described in cattle, was a sporadic case, and it was not possible to determine its cause. Neurological lesions and clinical sings presented here should be considered in the differential diagnosis of congenital diseases of the central nervous systems of cattle. Key words: lissencephaly, pachygyria, cerebellar hypoplasia, congenital malformation, cattle. Descreve-se um caso de lisencefalia-paquigiria e hipoplasia cerebelar diagnosticado em um bovino, macho, cruza Charoles x Tabapua que apresentava, desde o nascimento, sinais clinicos caracterizados por apatia, decubito prolongado, tremores da cabeca e do pescoco, ataxia, hipermetria, dificuldade na marcha, cegueira e aumento de volume nas articulacoes dos quatro membros. Devido ao prognostico desfavoravel, o bovino foi eutanasiado e necropsiado aos 34 dias de idade. Na abertura da caixa craniana, observou-se formacao rudimentar dos giros do telencefalo e cerebelo hipoplasico. Ao corte o encefalo, apresentava espessamento da substancia cinzenta (paquigiria) do cortex frontal, parietal, temporal e occipital e estreitamento da substancia branca. Nos orgaos das cavidades toracica e abdominal, nao foram observadas lesoes significativas. Histologicamente, no cortex cerebral h