Content of HLA-[G.sup.+] T cells in the peripheral blood from healthy women and breast cancer patients

Content of HLA-[G.sup.+] T cells in the peripheral blood from healthy women and breast cancer patients

The number of [CD3.sup.+][CD56.sup.-]HLA-[G.sup.+] cells in the peripheral blood of breast cancer patients was shown to increase by 2 times. Our results and published data suggest that the increase in the relative content of [CD3.sup.+][CD56.sup.-]HLA-[G.sup.+] cells in the circulating blood in brea...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2015-09, p.649
Hauptverfasser: Ostapchuk, E.O, Perfileva, Yu. V, Talaeva, Sh. Zh, Omarbaeva, N.A, Belyaev, N.N
Format: Artikel
Sprache:eng
Schlagworte:
Breast cancer
Care and treatment
Health aspects
Histocompatibility antigens
HLA histocompatibility antigens
T cells
Transforming growth factors
Tumor antigens
Women
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Zusammenfassung:The number of [CD3.sup.+][CD56.sup.-]HLA-[G.sup.+] cells in the peripheral blood of breast cancer patients was shown to increase by 2 times. Our results and published data suggest that the increase in the relative content of [CD3.sup.+][CD56.sup.-]HLA-[G.sup.+] cells in the circulating blood in breast cancer contributes to tumor development due to suppression of antitumor immunity. Key Words: regulatory T cells; HLA-G; interleukin-10; TGFβ
ISSN:0007-4888
DOI:10.1007/s10517-015-3038-y