P388 leukemia in [CDF.sub.1] mice as the test system for studies of tumor-associated neoangiogenesis and hypercoagulation
Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in [CDF.sub.1] mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animal...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2015-02, Vol.158 (4), p.497 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 158 |
| creator | Trashkov, A.P Panchenko, A.V Kayukova, E.S Korablev, R.V Pechatnikova, V.A Vasilev, A.G Anisimov, V.N |
| description | Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in [CDF.sub.1] mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia. Key Words: tumor; hemostasis; neoangiogenesis; vascular endothelial growth factor; P-388 leukemia |
| doi_str_mv | 10.1007/s10517-015-2793-0 |
| format | Article |
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| ispartof | Bulletin of experimental biology and medicine, 2015-02, Vol.158 (4), p.497 |
| issn | 0007-4888 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Blood tests Cancer research Endothelium Hypercoagulation Leukemia Prothrombin Thrombin Vascular endothelial growth factor |
| title | P388 leukemia in [CDF.sub.1] mice as the test system for studies of tumor-associated neoangiogenesis and hypercoagulation |
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