P388 leukemia in [CDF.sub.1] mice as the test system for studies of tumor-associated neoangiogenesis and hypercoagulation

Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in [CDF.sub.1] mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia. Key Words: tumor; hemostasis; neoangiogenesis; vascular endothelial growth factor; P-388 leukemia