Biodistribution of [sup.99m]Tc-2-aminoestrone-3-methyl ether as a potential radiotracer for inflammation imaging

Estrogens may have pro- and anti-inflammatory properties depending on the situation and the involved tissue. 2-Aminoestrone-3-methyl ether as an estrogenic derivative was prepared with a yield of 55 % and well characterized. [sup.99m]Tc-2-aminoestrone-3-methyl ether radiotracer was synthesized to st...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of radioanalytical and nuclear chemistry 2015-01, p.237
Hauptverfasser: Mutairi, Maha S. Al, Motaleb, Mohammed A, Haress, Nadia G, Zaghary, Wafaa A
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Estrogens may have pro- and anti-inflammatory properties depending on the situation and the involved tissue. 2-Aminoestrone-3-methyl ether as an estrogenic derivative was prepared with a yield of 55 % and well characterized. [sup.99m]Tc-2-aminoestrone-3-methyl ether radiotracer was synthesized to study its inflammatory binding specificity as a novel selective radiopharmaceutical for inflammation imaging. Invivo biodistribution study of [sup.99m]Tc-2-amino estrone-3-methyl ether complex in both bacterial infection and sterile inflammation showed high and rapid accumulation of [sup.99m]Tc-2-aminoestrone-3-methyl ether complex at the site of sterile inflammation compared to bacterial infection sites (target-tonon target ratio equal to 4.12 ± 0.02). This high biological accumulation in inflamed cells suggests that [sup.99m]Tc-2-aminoestrone-3-methyl ether complex may be suitable as a potential selective radiotracer able to image inflammatory sites. Keywords: Estrone * Technetium-99m * Inflammation * Imaging
ISSN:0236-5731
DOI:10.1007/s10967-014-3320-x