Biodistribution of [sup.99m]Tc-2-aminoestrone-3-methyl ether as a potential radiotracer for inflammation imaging
Estrogens may have pro- and anti-inflammatory properties depending on the situation and the involved tissue. 2-Aminoestrone-3-methyl ether as an estrogenic derivative was prepared with a yield of 55 % and well characterized. [sup.99m]Tc-2-aminoestrone-3-methyl ether radiotracer was synthesized to st...
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Veröffentlicht in: | Journal of radioanalytical and nuclear chemistry 2015-01, p.237 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Estrogens may have pro- and anti-inflammatory properties depending on the situation and the involved tissue. 2-Aminoestrone-3-methyl ether as an estrogenic derivative was prepared with a yield of 55 % and well characterized. [sup.99m]Tc-2-aminoestrone-3-methyl ether radiotracer was synthesized to study its inflammatory binding specificity as a novel selective radiopharmaceutical for inflammation imaging. Invivo biodistribution study of [sup.99m]Tc-2-amino estrone-3-methyl ether complex in both bacterial infection and sterile inflammation showed high and rapid accumulation of [sup.99m]Tc-2-aminoestrone-3-methyl ether complex at the site of sterile inflammation compared to bacterial infection sites (target-tonon target ratio equal to 4.12 ± 0.02). This high biological accumulation in inflamed cells suggests that [sup.99m]Tc-2-aminoestrone-3-methyl ether complex may be suitable as a potential selective radiotracer able to image inflammatory sites. Keywords: Estrone * Technetium-99m * Inflammation * Imaging |
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ISSN: | 0236-5731 |
DOI: | 10.1007/s10967-014-3320-x |