New Flavones from Garcinia bracteata and Their Biological Activities

New Flavones from Garcinia bracteata and Their Biological Activities

Investigation of an organic extract of the stems of Garcinia bracteata led to the isolation of two new flavones, named bracflavones A (1) and B (2). Their structures were elucidated by spectroscopic evidence. The compounds feature an isopropoxy group at C-3 compared with related known flavonoids iso...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry of natural compounds 2014-12, Vol.50 (6), p.985-988
Hauptverfasser: Hu, Qiufen, Niu, Deyun, Wang, Sujuan, Qin, Yunhua, Yang, Zongyan, Zhao, Guoli, Yang, Zhongxiu, Gao, Xuemei, Chen, Zhangyu
Format: Artikel
Sprache:eng
Schlagworte:
Bioflavonoids
chemistry
cytotoxicity
Flavones
Flavonoids
Garcinia bracteata
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
spectroscopy
stems
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Investigation of an organic extract of the stems of Garcinia bracteata led to the isolation of two new flavones, named bracflavones A (1) and B (2). Their structures were elucidated by spectroscopic evidence. The compounds feature an isopropoxy group at C-3 compared with related known flavonoids isolated from the genus Garcinia. Compounds 1 and 2 were tested for their cytotoxicity. The results revealed that compound 1 showed high cytotoxicity against A549 and PC3 cell lines, and compound 2 showed high cytotoxicity against NB4, A549, SH-SY5Y, PC3, and MCF7 cell lines.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-014-1142-2