Mild hypothermia in combination with minimally invasive evacuation of hematoma reduces inflammatory damage in patients via the nuclear factor-[kappa]B pathway

The aim of this study was to investigate the effects of mild hypothermia and minimally invasive evacuation of hematoma on the brain function of patients with cerebral hemorrhage. Seventy-six patients with acute cerebral hemorrhage were divided into the minimally invasive evacuation of hematoma (MIHE) and mild hypothermia and minimally invasive evacuation of hematoma (MHMIHE) groups. National Institutes of Health Stroke Scale (NIHSS) scores on the day of admission of the patient and one, three and seven days after the procedure were recorded. Perihematoma brain tissue morphology was observed using hematoxylin and eosin staining. Nuclear factor-[kappa]B (NF-[kappa]B) expression was determined by immunohistochemistry. The tumor necrosis factor- a (TNF-[alpha]) level was detected by ELISA. NIHSS scores in the MHMIHE group were significantly lower than those in the MIHE group on days three and seven. TNF-[alpha] and NF-[kappa]B levels peaked on day three, and the MHMIHE group had significantly lower levels of TNF-[alpha] and NF-[kappa]B than the MIHE group. In conclusion, the present study demonstrated that mild hypothermia and minimally invasive evacuation of hematoma can effectively reduce inflammation and improve the brain function of patients. Key words: mild hypothermia, cerebral hemorrhage, minimally invasive hematoma evacuation, nuclear factor-[kappa]B