Preparation of 6-unsubstituted 3,4-dihydropyrimidin-2pyrimidines

Preparation of 6-unsubstituted 3,4-dihydropyrimidin-2pyrimidines

The Biginelli reaction of methyl propiolate and of methyl 3-diethylaminoacrylate has yielded a novel series of 6-unsubstituted 3,4-dihydropyrimidin-2(¹H)-ones. The successie oxidation of the pyrimidine ring, chlorination of the 2-oxo group, and substitution of the chlorine atom by an aromatic amine...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2014-03, Vol.49 (12), p.1757
Hauptverfasser: Terentjeva, S, Muceniece, D, Lusis, V
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Esters
Organic acids
Pyrimidines
Resveratrol
Urea
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Zusammenfassung:The Biginelli reaction of methyl propiolate and of methyl 3-diethylaminoacrylate has yielded a novel series of 6-unsubstituted 3,4-dihydropyrimidin-2(¹H)-ones. The successie oxidation of the pyrimidine ring, chlorination of the 2-oxo group, and substitution of the chlorine atom by an aromatic amine give previously unknown 2-(arylamino)pyrimidines. 2-Oxo- and 2-(arylamino)pyrimidine-5-carboxylic acids have been obtained. Keywords: 2-(arylamino)pyrimidines, 2-chloropyrimidines, 2-oxo-1,2-dihydropyrimidines, 2-oxo-1,2,3,4-tetrahydropyrimidines, Biginelli reaction.
ISSN:0009-3122