Analysis and Standardization of Levofloxacin Substance

Amethod for the analysis and standardization of levofloxacin substance synthesized using an original method was developed. The physicochemical properties of batch samples of levofloxacin substance were studied; IR and UV spectra were recorded for identification; contents of contaminants and R-ofloxa...

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Veröffentlicht in:	Pharmaceutical chemistry journal 2014-02, Vol.47 (11), p.620-626
Hauptverfasser:	Sedova, M. K., Sergeeva, M. S., Dudenkova, M. E., Gaevaya, L. M., Grushevskaya, L. N., Avdyunina, N. I., Pyatin, B. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Levofloxacin Liquid chromatography Medicine Ofloxacin Organic Chemistry Pharmacology/Toxicology Pharmacy
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Amethod for the analysis and standardization of levofloxacin substance synthesized using an original method was developed. The physicochemical properties of batch samples of levofloxacin substance were studied; IR and UV spectra were recorded for identification; contents of contaminants and R-ofloxacin in substance were determined by HPLC; residual solvent contents were determined by GLC. Samples of substance were assayed by HPLC. The shelf life was determined and quality norms were specified for levofloxacin substance; the results were used to prepare a draft pharmacopoeia monograph for levofloxacin substance.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-014-1022-x