Studies of the Solubility of Rutin from Solid Dispersions

Studies of the Solubility of Rutin from Solid Dispersions

The effects of solid dispersions (SD) on the solubility of rutin were studied. Rutin and its SD with polyethylene glycol 1500 and polyvinylpyrrolidone 10000 were studied. Preparation of SD increased the solubility and rate of dissolution of the active substance. The solubility of rutin from SD incre...

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Veröffentlicht in:Pharmaceutical chemistry journal 2014-02, Vol.47 (11), p.612-615
Hauptverfasser: Koval’skii, I. V., Krasnyuk, I. I., Nikulina, O. I., Belyatskaya, A. V., Kharitonov, Yu. Ya, Fel’dman, N. B., Lutsenko, S. V., Grikh, V. V.
Format: Artikel
Sprache:eng
Schlagworte:
Chemical properties
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Polymers
Polyols
Solid solutions
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Zusammenfassung:The effects of solid dispersions (SD) on the solubility of rutin were studied. Rutin and its SD with polyethylene glycol 1500 and polyvinylpyrrolidone 10000 were studied. Preparation of SD increased the solubility and rate of dissolution of the active substance. The solubility of rutin from SD increased by a factor of 52. The physicochemical methods used here suggested that improvements in rutin release from SD result from decreases in crystallinity and formation of solid solutions of drug in polymer.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1020-z