Reacao de Mannich: metodologia classica na formacao de ligacao carbono-carbono

Reacao de Mannich: metodologia classica na formacao de ligacao carbono-carbono

The Mannich reaction is a classical method for the preparation of [beta]-aminoketones and aldeydes (Mannich bases) and, as such, is one the most important reaction in organic chemistry. The resulting Mannich bases are of particular interest due to their biological activity, use as synthetic building...

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Veröffentlicht in:Orbital : The Electronic Journal of Chemistry 2013-04, Vol.5 (2), p.96
Hauptverfasser: Filho, Joao F. Allochio, Fiorot, Rodolfo G, Delarmelina, Maicon, Lacerda, Valdemar, Jr, dos Santos, Reginaldo B, Greco, Sandro J
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Analysis
Bases (Chemistry)
Chemical properties
Chemical reactions
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Zusammenfassung:The Mannich reaction is a classical method for the preparation of [beta]-aminoketones and aldeydes (Mannich bases) and, as such, is one the most important reaction in organic chemistry. The resulting Mannich bases are of particular interest due to their biological activity, use as synthetic building blocks, and precursors of valuable pharmaceuticals products. In this context, various elegant stereoselective a-aminoalkylations have been developed. Keywords: stereoselective Mannich reactions; Mannich bases; aminoalkylations
ISSN:1984-6428
1984-6428