Alkylation of Tetrahydropyrimidine-2-thiones with Ethyl Chloroacetate

Alkylation of Tetrahydropyrimidine-2-thiones with Ethyl Chloroacetate

Reaction conditions were found for the alkylation of tetrahydropyrimidine-2-thiones with ethyl chloroacetate, preventing a subsequent cyclization. Only one of the ester groups in the obtained alkylation products was subject to alkaline hydrolysis, while a treatment with ammonia in alcohol resulted i...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2014-02, Vol.49 (11), p.1681-1686
Hauptverfasser: Shiryaev, A. K., Kolesnikova, N. G., Kuznetsova, N. M., Lashmanova, E. A.
Format: Artikel
Sprache:eng
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Antifungal agents
Chemical properties
Chemistry
Chemistry and Materials Science
Esters
Hydrolysis
Organic Chemistry
Pharmacy
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Zusammenfassung:Reaction conditions were found for the alkylation of tetrahydropyrimidine-2-thiones with ethyl chloroacetate, preventing a subsequent cyclization. Only one of the ester groups in the obtained alkylation products was subject to alkaline hydrolysis, while a treatment with ammonia in alcohol resulted in thiazolo[3,2-a]pyrimidines.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-014-1420-8