Modified method for the synthesis of isomeric N-substituted (1H-pyrazolyl)propane-1,3-diones

Modified method for the synthesis of isomeric N-substituted (1H-pyrazolyl)propane-1,3-diones

The condensation reaction of isomeric N-substituted (1 H -pyrazol-4-yl)ethanones with the ethyl esters of pyrazole carboxylic acids and fluoroacetic acids has been studied using NaH as the base. Under optimized conditions, it proved to be a convenient and preparative method for the synthesis of N-su...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2011-09, Vol.47 (6), p.695-699
Hauptverfasser: Taydakov, I. V., Krasnoselsky, S. S.
Format: Artikel
Sprache:eng
Schlagworte:
Chemical tests and reagents
Chemistry
Chemistry and Materials Science
Esters
Ketones
Methods
Organic acids
Organic Chemistry
Pharmacy
Propane
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Beschreibung
Zusammenfassung:The condensation reaction of isomeric N-substituted (1 H -pyrazol-4-yl)ethanones with the ethyl esters of pyrazole carboxylic acids and fluoroacetic acids has been studied using NaH as the base. Under optimized conditions, it proved to be a convenient and preparative method for the synthesis of N-substituted (1 H -pyrazolyl)propane-1,3-diones and (1 H -pyrazolyl)-4-polyfluorobutane-1,3-diones.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-011-0821-1