Synthesis and anticonvulsant activity of 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones

A series of 3-alkoxy-1,2-dihydro-3 H -1,4-benzodiazepin-2-ones were synthesized and their anticonvulsant properties were studied. It was found that 7-bromo-5-phenyl-3-cyclopropylmethyloxy derivative VIII had the highest anticonvulsant action among the synthesized compounds, the value of which was comparable with that of the reference compound 7-bromo-3-hydroxy-5-(2′-chloro)phenyl-1,2-dihydro-3 H -1,4-benzodiazepin-2-one ( II ). It was established that the 3-alkoxy-5-phenyl derivatives had higher anticonvulsant action than the 3-alkoxy-5-(2_-chloro)phenyl derivatives. The structures of compounds VIII and IX were determined by x-ray crystal and molecular structure analyses.