Antioxidant activity of thiamine and its structural analogs in reactions with electrochemically generated hydroxyl radicals and hydrogen peroxide

Antioxidant activity of thiamine and its structural analogs in reactions with electrochemically generated hydroxyl radicals and hydrogen peroxide

We have used differential pulse voltammetry on platinum and copper cathodes to study the antioxidant activity of thiamine (vitamin B 1 ) and its structural analogs. The results indicate that the activity of thiamine relative to the hydroxyl radical is lower than the activity of 3-benzyl-4-methyl-5-(...

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Veröffentlicht in:Theoretical and experimental chemistry 2011-03, Vol.47 (1), p.55-60
Hauptverfasser: Shapoval, G. S., Babii, L. V., Kruglyak, O. S., Vovk, A. I.
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidants
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hydrogen peroxide
Hydroxides
Physiological aspects
Protein binding
Proteins
Pyrimidines
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Zusammenfassung:We have used differential pulse voltammetry on platinum and copper cathodes to study the antioxidant activity of thiamine (vitamin B 1 ) and its structural analogs. The results indicate that the activity of thiamine relative to the hydroxyl radical is lower than the activity of 3-benzyl-4-methyl-5-(2-hydroxyethyl)thiazolium chloride. At the same time, thiamine can more efficiently react with hydrogen peroxide and bind divalent iron ions.
ISSN:0040-5760
1573-935X
DOI:10.1007/s11237-011-9185-y