Synthesis and pharmacological activity of 3-carboxypicolinic acid amides

Synthesis and pharmacological activity of 3-carboxypicolinic acid amides

A series of substituted amides of 3-carboxypicolinic acid have been synthesized via the interaction of quinolinic acid anhydride with alkyl(aryl)amines. Their structures were studied by ¹H and ¹³C NMR spectroscopy. The direction of the reaction was explained by quantum-chemistry methods. Three compo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutical chemistry journal 2010-12, Vol.44 (9), p.476-479
Hauptverfasser: Kon'shin, M. E, Syropyatov, B. Ya, Vakhrin, M. I, Neifel'd, P. G, Feshin, V. P, Shurov, S. N, Odegova, T. F
Format: Artikel
Sprache:eng
Schlagworte:
3-carboxypicolinic acid amides
Amides
anticoagulant activity
Anticoagulants (Medicine)
hemostatic activity
Medicine
Nuclear magnetic resonance spectroscopy
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A series of substituted amides of 3-carboxypicolinic acid have been synthesized via the interaction of quinolinic acid anhydride with alkyl(aryl)amines. Their structures were studied by ¹H and ¹³C NMR spectroscopy. The direction of the reaction was explained by quantum-chemistry methods. Three compounds demonstrated hemostatic activity. Two substances exhibited anticoagulant properties. Most substances also exhibited weak bacteriostatic activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0495-5