Synthesis and pharmacological properties of alkylammonium salts of N,N′-malonyl-bis-p-aminobenzoic acid

A series of ammonium salts of N,N′-malonyl-bis-p-aminobenzoic acid with some alkylamines have been obtained. It is established that these compounds possess hypotensive, antiarrhythmic, and anticoagulative activities depending on the structure of the alkylamine constituents.

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Veröffentlicht in:Pharmaceutical chemistry journal 2010-12, Vol.44 (9), p.469-471
Hauptverfasser: Shepel', F. G, Zozulya, R. N, Shepel', D. F, Makaev, F. Z
Format: Artikel
Sprache:eng
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Zusammenfassung:A series of ammonium salts of N,N′-malonyl-bis-p-aminobenzoic acid with some alkylamines have been obtained. It is established that these compounds possess hypotensive, antiarrhythmic, and anticoagulative activities depending on the structure of the alkylamine constituents.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0493-7