Synthesis and cytotoxic activity of azidonaphthazarins
Preparative methods have been developed for the synthesis of azidonaphthazarins. It is established that 2-hydroxy- and 2-alkoxy-6,7-dichloronaphthazarins react regiospecifically with sodium azide in MeOH to yield the corresponding 6-azido derivatives. The cytotoxic activity and contraceptive propert...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2011-12, Vol.45 (9), p.522-525 |
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| creator | Pokhilo, N. D. Kiseleva, M. I. Anufriev, V. F. |
| description | Preparative methods have been developed for the synthesis of azidonaphthazarins. It is established that 2-hydroxy- and 2-alkoxy-6,7-dichloronaphthazarins react regiospecifically with sodium azide in MeOH to yield the corresponding 6-azido derivatives. The cytotoxic activity and contraceptive properties of the synthesized azidonaphthazarins have been investigated using the sperm and eggs of the sea urchin
Strongylocentrotus intermedius
. |
| doi_str_mv | 10.1007/s11094-011-0671-2 |
| format | Article |
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Strongylocentrotus intermedius
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Strongylocentrotus intermedius
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Strongylocentrotus intermedius
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| ispartof | Pharmaceutical chemistry journal, 2011-12, Vol.45 (9), p.522-525 |
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| subjects | Contraceptives Explosives Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy |
| title | Synthesis and cytotoxic activity of azidonaphthazarins |
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