Synthesis and cytotoxic activity of azidonaphthazarins

Synthesis and cytotoxic activity of azidonaphthazarins

Preparative methods have been developed for the synthesis of azidonaphthazarins. It is established that 2-hydroxy- and 2-alkoxy-6,7-dichloronaphthazarins react regiospecifically with sodium azide in MeOH to yield the corresponding 6-azido derivatives. The cytotoxic activity and contraceptive propert...

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Veröffentlicht in:Pharmaceutical chemistry journal 2011-12, Vol.45 (9), p.522-525
Hauptverfasser: Pokhilo, N. D., Kiseleva, M. I., Anufriev, V. F.
Format: Artikel
Sprache:eng
Schlagworte:
Contraceptives
Explosives
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Zusammenfassung:Preparative methods have been developed for the synthesis of azidonaphthazarins. It is established that 2-hydroxy- and 2-alkoxy-6,7-dichloronaphthazarins react regiospecifically with sodium azide in MeOH to yield the corresponding 6-azido derivatives. The cytotoxic activity and contraceptive properties of the synthesized azidonaphthazarins have been investigated using the sperm and eggs of the sea urchin Strongylocentrotus intermedius .
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0671-2