Synthesis and antituberculous activity of quinoline isosteres of isoniazid

We present an evaluation of the antimycobacterial activity of a series of 2-aryl(heteryl)-4-quinolinecarboxylic acids. Compounds with potential value against Mycobacterium tuberculosis H37Rv were found.

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Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical chemistry journal 2011-07, Vol.45 (4), p.217, Article 217
Hauptverfasser:	Zimichev, A. V., Zemtsova, M. N., Kashaev, A. G., Klimochkin, Yu. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Antitubercular agents Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy Quinoline
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Beschreibung
Zusammenfassung:	We present an evaluation of the antimycobacterial activity of a series of 2-aryl(heteryl)-4-quinolinecarboxylic acids. Compounds with potential value against Mycobacterium tuberculosis H37Rv were found.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-011-0598-7