Synthesis and experimental study of a dextran-ferrite-based magnetically driven nanopreparation as an MRI contrast agent for tumor-feeding vessels

Synthesis and experimental study of a dextran-ferrite-based magnetically driven nanopreparation as an MRI contrast agent for tumor-feeding vessels

Dextran-ferrite (DF) nanoparticles were synthesized and the related DF sol was successfully tested in vivo as a negative contrast agent for enhancing early magnetic resonance imaging (MRI) detection of tumor, capsule, and tumor-feeding vessels. Intravenous injection of DF in combination with Magnevi...

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Veröffentlicht in:Pharmaceutical chemistry journal 2011-05, Vol.45 (2), p.84-87
Hauptverfasser: Brusentsov, N. A., Pirogov, Yu. A., Uchevatkin, A. A., Polyanskii, V. A., Brusentsova, T. N., Ivanov, A. V.
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Chemotherapy
Contrast media
Dextran
Iron compounds
Magnetic resonance imaging
Medicine
Mice
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Tumors
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Zusammenfassung:Dextran-ferrite (DF) nanoparticles were synthesized and the related DF sol was successfully tested in vivo as a negative contrast agent for enhancing early magnetic resonance imaging (MRI) detection of tumor, capsule, and tumor-feeding vessels. Intravenous injection of DF in combination with Magnevist and subsequent T 2 ,T 2 * -weighted 3D scanning gave enhanced MRI images that defined the arrangement and functional state of surface and other vessels feeding capsule and tumor in C57Bl/6j mice with a mammary adenocarcinoma (Ac755) model.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0565-3