Synthesis and antidepressant and anxiolytic activity of derivatives of pyrazolo[4,3-c]pyridine and 4-phenylhydrazinonicotinic acids
The synthesis of compounds effective in the treatment of anxiety—depression disorders is described. It is established that 4,6-dimethyl-2-(4-chlorophenyl)-2,3-dihydro-1 H -pyrazolo[4,3- c ]pyridine-3-one hydrochloride ( IVa ) possesses combined antidepressant and anxiolytic properties. Advantages of...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2012-04, Vol.46 (1), p.15-19 |
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| container_title | Pharmaceutical chemistry journal |
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| creator | Zhmurenko, L. A. Molodavkin, G. M. Voronina, T. A. Lezina, V. P. |
| description | The synthesis of compounds effective in the treatment of anxiety—depression disorders is described. It is established that 4,6-dimethyl-2-(4-chlorophenyl)-2,3-dihydro-1
H
-pyrazolo[4,3-
c
]pyridine-3-one hydrochloride (
IVa
) possesses combined antidepressant and anxiolytic properties. Advantages of
IVa
are low toxicity and the absence of side effects typical of antidepressants (elevated anxiety) and benzodiazepine anxiolytics (myorelaxant and sedative action). |
| doi_str_mv | 10.1007/s11094-012-0726-z |
| format | Article |
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H
-pyrazolo[4,3-
c
]pyridine-3-one hydrochloride (
IVa
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H
-pyrazolo[4,3-
c
]pyridine-3-one hydrochloride (
IVa
) possesses combined antidepressant and anxiolytic properties. Advantages of
IVa
are low toxicity and the absence of side effects typical of antidepressants (elevated anxiety) and benzodiazepine anxiolytics (myorelaxant and sedative action).</description><subject>Alkaloids</subject><subject>Antianxiety agents</subject><subject>Antidepressants</subject><subject>Depression, Mental</subject><subject>Esters</subject><subject>Medicine</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Pyridine</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kU9rXCEUxaW00GnaD9DdQLc18aovPpch9B8EsmgLhVLE6DVzwxsd9DX0zbZfvE4mm0IpInou53dQDmOvQZyCEOasAQiruQDJhZHnfP-ErWAwiluh4ClbCWGBwyC-PWcvWrsTolNKrtjvz0ueN9iorX2Ofc8UcVextX59HP2iMi0zhbUPM93TvKxLWkesdO-7xnaQu6X6fZnKd_1W8fCjS4qU8SFB890G8zJtlthNlEumUGbKD4kU20v2LPmp4avH84R9ff_uy-VHfnX94dPlxRUPg9QzN2NCc2OkHK3FpEAZrQLEIUo_gocg0ghCJhmtMHGw4QZhVFanIUXApLU6YW-Oubd-Qkc5lbn6sKUW3IUarFLaDOfddfoPV18Rt_3dGRP1-V8AHIFQS2sVk9tV2vq6OBDuUI47luN6Oe5Qjtt3Rh6Z1r35Fqu7Kz9r7r__D_QH70OU2g</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Zhmurenko, L. A.</creator><creator>Molodavkin, G. M.</creator><creator>Voronina, T. A.</creator><creator>Lezina, V. P.</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20120401</creationdate><title>Synthesis and antidepressant and anxiolytic activity of derivatives of pyrazolo[4,3-c]pyridine and 4-phenylhydrazinonicotinic acids</title><author>Zhmurenko, L. A. ; Molodavkin, G. M. ; Voronina, T. A. ; Lezina, V. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-78fe7b722899ef313743c1d5d2a81a1c0f8102f2d907d59cbe18394f5fd1ef443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alkaloids</topic><topic>Antianxiety agents</topic><topic>Antidepressants</topic><topic>Depression, Mental</topic><topic>Esters</topic><topic>Medicine</topic><topic>Organic Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Pyridine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhmurenko, L. A.</creatorcontrib><creatorcontrib>Molodavkin, G. M.</creatorcontrib><creatorcontrib>Voronina, T. A.</creatorcontrib><creatorcontrib>Lezina, V. P.</creatorcontrib><collection>CrossRef</collection><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhmurenko, L. A.</au><au>Molodavkin, G. M.</au><au>Voronina, T. A.</au><au>Lezina, V. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and antidepressant and anxiolytic activity of derivatives of pyrazolo[4,3-c]pyridine and 4-phenylhydrazinonicotinic acids</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2012-04-01</date><risdate>2012</risdate><volume>46</volume><issue>1</issue><spage>15</spage><epage>19</epage><pages>15-19</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>The synthesis of compounds effective in the treatment of anxiety—depression disorders is described. It is established that 4,6-dimethyl-2-(4-chlorophenyl)-2,3-dihydro-1
H
-pyrazolo[4,3-
c
]pyridine-3-one hydrochloride (
IVa
) possesses combined antidepressant and anxiolytic properties. Advantages of
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| issn | 0091-150X 1573-9031 |
| language | eng |
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| source | SpringerNature Journals |
| subjects | Alkaloids Antianxiety agents Antidepressants Depression, Mental Esters Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy Pyridine |
| title | Synthesis and antidepressant and anxiolytic activity of derivatives of pyrazolo[4,3-c]pyridine and 4-phenylhydrazinonicotinic acids |
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