A new group of 1- and 7-[[omega]-(benzhydryl-1-alkyl]-3-methylxanthine derivatives with antihistamine activity

Directed synthesis using the accessible compound 3-methylxanthine was used to obtain a new group of 1- and 7-[[omega]-(benzhydryl-1)alkyl]-3-methylxanthrne derivatives which functioned as histamine receptor blockers. The compound which was most active, had the longest duration of action, and the lowest toxicity was 7-[4-(4-benzhydrylpiperazinyl-1)butyl]-3-methylxanthine succinate, and this compound was selected for clinical trials. Key words: 1- and 7-[[omega]-(benzhydryl-1)alkyl]-3-methylxanthrne derivatives, synthesis, antihistamine activity, acute toxicity, further pharmacological study of 7-[4-(4-benzhydrylpiperazinyl-1)butyl]-3-methylxanthine succinate.