Evaluation of compatibility of tablet excipients and novel synthesized polymer with lamivudine

The present study describes compatibility of anti-HIV drug lamivudine with various selected excipients and a novel synthesized polymer, for the development of its controlled release formulation. Differential scanning calorimetry (DSC), isothermal stability study (ISS) and Fourier transform infrared...

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Veröffentlicht in:	Journal of thermal analysis and calorimetry 2012-04, Vol.108 (1), p.263-267
Hauptverfasser:	Singh, Akhilesh V., Nath, Lila K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Biological and medical sciences Calorimetry Chemistry Chemistry and Materials Science General pharmacology Inorganic Chemistry Lactose Lamivudine Magnesium compounds Measurement Science and Instrumentation Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical Chemistry Polymer industry Polymer Sciences Polymers
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Beschreibung
Zusammenfassung:	The present study describes compatibility of anti-HIV drug lamivudine with various selected excipients and a novel synthesized polymer, for the development of its controlled release formulation. Differential scanning calorimetry (DSC), isothermal stability study (ISS) and Fourier transform infrared (FT-IR) spectral analysis were performed to access the compatibility. The compatibility study was performed with various common excipients like spray dried lactose, polyvinyl pyrrolidine K-30, magnesium stearate, talc and a novel synthesized polymer cross-linked sago starch with lamivudine.
ISSN:	1388-6150 1588-2926 1572-8943
DOI:	10.1007/s10973-011-1650-2