Analysis of phase transition and dehydration processes of nevirapine
Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and...
Gespeichert in:
| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2012-04, Vol.108 (1), p.53-57 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 57 |
|---|---|
| container_issue | 1 |
| container_start_page | 53 |
| container_title | Journal of thermal analysis and calorimetry |
| container_volume | 108 |
| creator | de Oliveira, George G. G. Ferraz, Humberto G. Severino, Patrícia Souto, Eliana B. |
| description | Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility. |
| doi_str_mv | 10.1007/s10973-011-1424-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_infotracmisc_A359212944</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A359212944</galeid><sourcerecordid>A359212944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-411eeb4bb7629daf269ca79abe093015f44e2d2fd9db7433d389082246dec353</originalsourceid><addsrcrecordid>eNp9kU1LxDAQhosoKOoP8FYQDx665qtpc1z8BkFQ7yFNJmtkNy2ZKrv_3mhFWBDJITPJ8w4hT1GcUDKjhDQXSIlqeEUorahgolrvFAe0btuKKSZ3c81zLWlN9otjxNARRolUdasOiqt5NMsNBix7Xw6vBqEck4kYxtDH0kRXOnjduGS--yH1FhDhm47wEZIZQoSjYs-bJcLxz35YvNxcv1zeVQ-Pt_eX84fKCqrGSlAK0ImuayRTzngmlTWNMh0QxQmtvRDAHPNOua4RnDveKtIyJqQDy2t-WJxOYxdmCTpE3-en2lVAq-e8VowyJUSmZn9QeTlYBdtH8CGfbwXOtwKZGWE9Lsw7or5_ftpm6cTa1CMm8HpIYWXSRlOiv1zoyYXOLvSXC73OmbMpMxi0Zunz99qAv0FWSyZlzTPHJg7zVVxA0m_9e8p68J_hn2Isl9A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Analysis of phase transition and dehydration processes of nevirapine</title><source>SpringerLink Journals</source><creator>de Oliveira, George G. G. ; Ferraz, Humberto G. ; Severino, Patrícia ; Souto, Eliana B.</creator><creatorcontrib>de Oliveira, George G. G. ; Ferraz, Humberto G. ; Severino, Patrícia ; Souto, Eliana B.</creatorcontrib><description>Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility.</description><identifier>ISSN: 1388-6150</identifier><identifier>EISSN: 1588-2926</identifier><identifier>EISSN: 1572-8943</identifier><identifier>DOI: 10.1007/s10973-011-1424-x</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Analytical Chemistry ; Anti-HIV agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Chemistry ; Chemistry and Materials Science ; DNA polymerases ; General pharmacology ; Highly active antiretroviral therapy ; Inorganic Chemistry ; Measurement Science and Instrumentation ; Medical sciences ; Nevirapine ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physical Chemistry ; Polymer Sciences</subject><ispartof>Journal of thermal analysis and calorimetry, 2012-04, Vol.108 (1), p.53-57</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-411eeb4bb7629daf269ca79abe093015f44e2d2fd9db7433d389082246dec353</citedby><cites>FETCH-LOGICAL-c419t-411eeb4bb7629daf269ca79abe093015f44e2d2fd9db7433d389082246dec353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10973-011-1424-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10973-011-1424-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25626653$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>de Oliveira, George G. G.</creatorcontrib><creatorcontrib>Ferraz, Humberto G.</creatorcontrib><creatorcontrib>Severino, Patrícia</creatorcontrib><creatorcontrib>Souto, Eliana B.</creatorcontrib><title>Analysis of phase transition and dehydration processes of nevirapine</title><title>Journal of thermal analysis and calorimetry</title><addtitle>J Therm Anal Calorim</addtitle><description>Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility.</description><subject>Analytical Chemistry</subject><subject>Anti-HIV agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>DNA polymerases</subject><subject>General pharmacology</subject><subject>Highly active antiretroviral therapy</subject><subject>Inorganic Chemistry</subject><subject>Measurement Science and Instrumentation</subject><subject>Medical sciences</subject><subject>Nevirapine</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><issn>1388-6150</issn><issn>1588-2926</issn><issn>1572-8943</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kU1LxDAQhosoKOoP8FYQDx665qtpc1z8BkFQ7yFNJmtkNy2ZKrv_3mhFWBDJITPJ8w4hT1GcUDKjhDQXSIlqeEUorahgolrvFAe0btuKKSZ3c81zLWlN9otjxNARRolUdasOiqt5NMsNBix7Xw6vBqEck4kYxtDH0kRXOnjduGS--yH1FhDhm47wEZIZQoSjYs-bJcLxz35YvNxcv1zeVQ-Pt_eX84fKCqrGSlAK0ImuayRTzngmlTWNMh0QxQmtvRDAHPNOua4RnDveKtIyJqQDy2t-WJxOYxdmCTpE3-en2lVAq-e8VowyJUSmZn9QeTlYBdtH8CGfbwXOtwKZGWE9Lsw7or5_ftpm6cTa1CMm8HpIYWXSRlOiv1zoyYXOLvSXC73OmbMpMxi0Zunz99qAv0FWSyZlzTPHJg7zVVxA0m_9e8p68J_hn2Isl9A</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>de Oliveira, George G. G.</creator><creator>Ferraz, Humberto G.</creator><creator>Severino, Patrícia</creator><creator>Souto, Eliana B.</creator><general>Springer Netherlands</general><general>Springer</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>20120401</creationdate><title>Analysis of phase transition and dehydration processes of nevirapine</title><author>de Oliveira, George G. G. ; Ferraz, Humberto G. ; Severino, Patrícia ; Souto, Eliana B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-411eeb4bb7629daf269ca79abe093015f44e2d2fd9db7433d389082246dec353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analytical Chemistry</topic><topic>Anti-HIV agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>DNA polymerases</topic><topic>General pharmacology</topic><topic>Highly active antiretroviral therapy</topic><topic>Inorganic Chemistry</topic><topic>Measurement Science and Instrumentation</topic><topic>Medical sciences</topic><topic>Nevirapine</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Oliveira, George G. G.</creatorcontrib><creatorcontrib>Ferraz, Humberto G.</creatorcontrib><creatorcontrib>Severino, Patrícia</creatorcontrib><creatorcontrib>Souto, Eliana B.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Journal of thermal analysis and calorimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Oliveira, George G. G.</au><au>Ferraz, Humberto G.</au><au>Severino, Patrícia</au><au>Souto, Eliana B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of phase transition and dehydration processes of nevirapine</atitle><jtitle>Journal of thermal analysis and calorimetry</jtitle><stitle>J Therm Anal Calorim</stitle><date>2012-04-01</date><risdate>2012</risdate><volume>108</volume><issue>1</issue><spage>53</spage><epage>57</epage><pages>53-57</pages><issn>1388-6150</issn><eissn>1588-2926</eissn><eissn>1572-8943</eissn><abstract>Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10973-011-1424-x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1388-6150 |
| ispartof | Journal of thermal analysis and calorimetry, 2012-04, Vol.108 (1), p.53-57 |
| issn | 1388-6150 1588-2926 1572-8943 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A359212944 |
| source | SpringerLink Journals |
| subjects | Analytical Chemistry Anti-HIV agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Chemistry Chemistry and Materials Science DNA polymerases General pharmacology Highly active antiretroviral therapy Inorganic Chemistry Measurement Science and Instrumentation Medical sciences Nevirapine Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical Chemistry Polymer Sciences |
| title | Analysis of phase transition and dehydration processes of nevirapine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T13%3A01%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20phase%20transition%20and%20dehydration%20processes%20of%20nevirapine&rft.jtitle=Journal%20of%20thermal%20analysis%20and%20calorimetry&rft.au=de%20Oliveira,%20George%20G.%20G.&rft.date=2012-04-01&rft.volume=108&rft.issue=1&rft.spage=53&rft.epage=57&rft.pages=53-57&rft.issn=1388-6150&rft.eissn=1588-2926&rft_id=info:doi/10.1007/s10973-011-1424-x&rft_dat=%3Cgale_cross%3EA359212944%3C/gale_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A359212944&rfr_iscdi=true |