Analysis of phase transition and dehydration processes of nevirapine

Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and...

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Veröffentlicht in:	Journal of thermal analysis and calorimetry 2012-04, Vol.108 (1), p.53-57
Hauptverfasser:	de Oliveira, George G. G., Ferraz, Humberto G., Severino, Patrícia, Souto, Eliana B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Anti-HIV agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Chemistry Chemistry and Materials Science DNA polymerases General pharmacology Highly active antiretroviral therapy Inorganic Chemistry Measurement Science and Instrumentation Medical sciences Nevirapine Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical Chemistry Polymer Sciences
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Beschreibung
Zusammenfassung:	Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility.
ISSN:	1388-6150 1588-2926 1572-8943
DOI:	10.1007/s10973-011-1424-x