Synthesis and antifungal activity of sulfides, sulfoxides, and sulfones based on -[beta]-pinene

Synthesis and antifungal activity of sulfides, sulfoxides, and sulfones based on -[beta]-pinene

Attachment of 2-mercaptoethanol and thioglycolic acid methyl ester to the double bond of (15)-(-)-[beta]-pinene yielded pinane sulfides with the cis configuration. Oxidation of sulfides with m-chloroperbenzoic acid yielded the corresponding sulfoxides and sulfones. The resulting compounds were scree...

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Veröffentlicht in:Pharmaceutical chemistry journal 2010-07, Vol.44 (3), p.126
Hauptverfasser: Gavrilov, V.V, Startseva, V.A, Nikitina, L.E, Lodochnikova, O.A, Gnezdilov, O.I, Lisovskaya, S.A, Glushko, N.I, Klimovitskii, E.N
Format: Artikel
Sprache:eng
Schlagworte:
Antifungal agents
Chemical properties
Organosulfur compounds
Sulfides
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Zusammenfassung:Attachment of 2-mercaptoethanol and thioglycolic acid methyl ester to the double bond of (15)-(-)-[beta]-pinene yielded pinane sulfides with the cis configuration. Oxidation of sulfides with m-chloroperbenzoic acid yielded the corresponding sulfoxides and sulfones. The resulting compounds were screened for antimycotic activity and the dynamics of changes in antifungal properties in sulfides-sulfoxide-sulfone series were studied. Key words: Pinane sulfides, sulfoxides, and sulfones, antifungal activity.
ISSN:0091-150X