Modeling Translation in Protein Synthesis with TASEP: A Tutorial and Recent Developments

Modeling Translation in Protein Synthesis with TASEP: A Tutorial and Recent Developments

The phenomenon of protein synthesis has been modeled in terms of totally asymmetric simple exclusion processes (TASEP) since 1968. In this article, we provide a tutorial of the biological and mathematical aspects of this approach. We also summarize several new results, concerned with limited resourc...

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Veröffentlicht in:Journal of statistical physics 2011-07, Vol.144 (2), p.405-428
Hauptverfasser: Zia, R. K. P., Dong, J. J., Schmittmann, B.
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Analysis
Mathematical and Computational Physics
Physical Chemistry
Physics
Physics and Astronomy
Protein biosynthesis
Quantum Physics
Statistical Physics and Dynamical Systems
Theoretical
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Zusammenfassung:The phenomenon of protein synthesis has been modeled in terms of totally asymmetric simple exclusion processes (TASEP) since 1968. In this article, we provide a tutorial of the biological and mathematical aspects of this approach. We also summarize several new results, concerned with limited resources in the cell and simple estimates for the current (protein production rate) of a TASEP with inhomogeneous hopping rates, reflecting the characteristics of real genes.
ISSN:0022-4715
1572-9613
DOI:10.1007/s10955-011-0183-1