Look Ma, no PCNA: how DNA polymerase ζ synthesizes long stretches of DNA without a processivity factor

Look Ma, no PCNA: how DNA polymerase ζ synthesizes long stretches of DNA without a processivity factor

The long-awaited crystal structure of Saccharomyces cerevisiae DNA polymerase e reveals a unique domain never before observed in B-family DNA polymerases. This novel domain endows polymerase e with a capacity for highly processive DNA synthesis.

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Veröffentlicht in:Nature structural & molecular biology 2014-01, Vol.21 (1), p.12
Hauptverfasser: Zahn, Karl E, Doublie, Sylvie
Format: Artikel
Sprache:eng
Schlagworte:
DNA polymerases
DNA sequencing
Genetic research
Nucleotide sequencing
Physiological aspects
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Zusammenfassung:The long-awaited crystal structure of Saccharomyces cerevisiae DNA polymerase e reveals a unique domain never before observed in B-family DNA polymerases. This novel domain endows polymerase e with a capacity for highly processive DNA synthesis.
ISSN:1545-9993
1545-9985