Methodology of the spectrophotometric analysis of organic mixtures: Application of statistical models

Deviations of the absorbance of mixtures from additivity can be detected and predicted using statistical models obtained in the complete factorial experiment. The models correlate the deviations with the composition of a mixture; this allows the optimization of the procedures of spectrophotometric analysis. The advantages and limitations of this approach are demonstrated on an example of the analysis of pharmaceutical preparations and antioxidant mixtures.