Synthesis and antiviral evaluation of 1,3-dimethyl-6--dione derivatives

Synthesis and antiviral evaluation of 1,3-dimethyl-6--dione derivatives

Some 6-(1H-1,2,3-triazol-1-yl)pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strai...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2010-12, Vol.46 (9), p.1105
Hauptverfasser: Etrawy, A. Sh. El, Abdel-Rahman, A.A.-H
Format: Artikel
Sprache:eng
Schlagworte:
Antiviral agents
Hepatitis A
Pyrimidines
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Zusammenfassung:Some 6-(1H-1,2,3-triazol-1-yl)pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strain) and Herpes simples virus type-1 (HSV-1) were tested. Keywords: pyrimidine derivatives, 1,2,3-triazoles, anti hepatitis A virus, cycloaddition.
ISSN:0009-3122