4-hydroxy-2-quinolones. 176. 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. synthesis, physicochemical and biological properties

4-hydroxy-2-quinolones. 176. 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. synthesis, physicochemical and biological properties

We have carried out the synthesis and a comparative analysis of the acidic properties of a large group of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. Features of the recorded NMR spectra of these compounds are discussed together with their analgesic properties.

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2010-09, Vol.46 (5), p.559-568
Hauptverfasser: Ukrainets, I. V, Davidenko, A. A, Mospanova, E. V, Sidorenko, L. V, Svechnikova, E. N
Format: Artikel
Sprache:eng
Schlagworte:
4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids
analgesic effect
Analgesics
Chemistry
Chemistry and Materials Science
Esters
Hydrolysis
Organic acids
Organic Chemistry
Pharmacy
pKa
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Zusammenfassung:We have carried out the synthesis and a comparative analysis of the acidic properties of a large group of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. Features of the recorded NMR spectra of these compounds are discussed together with their analgesic properties.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-010-0546-6